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药学研究
Pharmaceutical research
药学研究

中间体

医药中间体是一些用于药品合成工艺过程中的一些化工原料或化工产品,可以有效推动创新药及仿制药的工艺研发流程,其中一些关键中间体还有可能成为制约工艺开发的关键因素。美迪西工艺部可以为客户提供从药物中间体生产工艺的开发、优化商业化生产以及注册申报的一整套服务,遵循ICH和NMPA的法规及指导原则。

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服务内容
  • 美迪西药物中间体或其它化学品业务服务内容
    设计具有知识产权和成本优势的中间体合成路线工艺路线筛选,工艺的优化,质量研究,工艺安全评估 放大生产(GMP或者非GMP) 分析方法的开发和验证提供精细化工品的合成路线开发、工艺优化,以及放大生产服务, 特别是一些高附加值精细化工品的工艺开发和生产。
  • 医药中间体的合成技术
    定向硝化技术高温高压反应技术缩合技术控制氧化技术氟化技术加氢还原技术不对称合成不对称催化反应如生物催化
  • 美迪西的医药中间体研发能力与水平
    引进、设计和研究医药中间体产品技术商业化路线的筛选通过反应设计(DoE)和质量设计(QbD)进行商业化工艺的开发与优化 单元操作研究和各步骤关键工艺参数的确认 杂质的结构,来源以及控制的研究 GMP起始原料的界定 迅速取得医药中间体小试结果,承接中试放大任务,为工业化生产提供可靠的工艺依据具备医药中间体的结构分析和性能测试的能力。
产品列表
  • 获取产品价格信息,请联系我们:

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    美迪西PROTAC中间体产品列表
    NumberCompound NamePurityInventory
    13-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride97.4500 mg
    23-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride94.61.6 g
    31-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide hydrochloride94.41.3 g
    4 t-Boc-N-amido-PEG5-acid 97/
    5 t-Boc-N-amido-PEG1-acid \\
    6Pomalidomide99.8\
    72-(2,6-dioxopiperidin-3-yl)-5-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione909.5 g
    82-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid90102 mg
    9perfluorophenyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate9023 mg
    101-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidine-4-carbaldehyde90100 mg
    112-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione90200 mg
    121-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde90100 mg
    132-(2,6-dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione96.4102.08 mg
    142-(2,6-dioxopiperidin-3-yl)-4-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione94.8101.91 mg
    151-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylic acid97.7104.5 mg
    162-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride98.3103 mg
    172-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride92.46101 mg
    182-(2,6-dioxopiperidin-3-yl)-5-[4-(hydroxymethyl)-3-methylpiperidin-1-yl]isoindole-1,3-dione95.1103 mg
    192-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione97.8102 mg
    20QL12003-700-195.726 mg
    21QL12003-707-293.928 mg
    22QL12003-707-199.720 mg
    23QL12003-667-36220 mg
    24QL12003-667-199.427 mg
    25QL12003-650-163.228 mg
    26inter14-1090 mg
    27QLS12010-1058-420mg
    28QLS12003-697-327.61mg
    29QL-MDC1001-32.342 g
    30QL-MDC1001-41.680 g
    31QLS12003-504-52.02 g
    32QLS12003-605-196.3240 mg
    33QLS12003-605-299.265 mg
    34QLS12003-605-388.760 mg
    35QLS12003- inter1486.750 mg
    36QLS12003- inter1-765 mg
    37QLS12003- 563-730 mg
    38QLS12003-693-285 mg
    39QLS12003-696-293.754 mg
    40QLS12003-609-282110 mg
    41tert-butyl 4-(2-((1s,3s)-3-(benzyloxy)cyclobutoxy)ethyl)piperazine-1-carboxylate952.05 g
    42tert-butyl (3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)(methyl)carbamate98213 mg
    43tert-butyl 3-(prop-2-yn-1-yloxy)propanoate950.66 g
    44tert-butyl 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanoate951.33 g
    45tert-butyl 4-(2-((1s,3s)-3-((methylsulfonyl)oxy)cyclobutoxy)ethyl)piperazine-1-carboxylate95167 mg
    46tert-butyl (2-(3-hydroxypropoxy)ethyl)carbamate951.45 g
    475-(4-((1,4-dioxaspiro[4.5]decan-8-yl)methyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione992.83 g
    482-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((4-oxocyclohexyl)methyl)piperazin-1-yl)isoindoline-1,3-dione95740 mg
    493-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid95430 mg
    50tert-butyl 3-(2-(2-(2-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoate95760 mg
    513-(2-(2-(2-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid90430 mg
    523-(4-(3-(3-hydroxypropoxy)propyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione90200 mg
    533-(3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propoxy)propyl methanesulfonate92100 mg
    544-((4,4-dimethoxybutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione97868 mg
    55ethyl 1-(3-cyanophenyl)piperidine-4-carboxylate851.68 g
    56ethyl 1-(4-cyanophenyl)piperidine-4-carboxylate9914.4 g
    57methyl 1-(7-hydroxyheptyl)-1H-indole-6-carboxylate87520 mg
    581-(7-hydroxyheptyl)-1H-indole-6-carboxylic acid96335 mg
    59methyl 1-(7-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)heptyl)-1H-indole-6-carboxylate95138 mg
    60tert-butyl 4-(2-((1s,3s)-3-hydroxycyclobutoxy)ethyl)piperazine-1-carboxylate85300 mg
    616-bromo-7-methoxy-2-methylquinazolin-4-ol88.460.0 mg
    62methyl 5-amino-2H-indazole-6-carboxylate9460.0 mg
    63tert-butyl 9-((methylsulfonyl)oxy)-3-azaspiro[5.5]undecane-3-carboxylate9060.0 mg
    64benzyl 4-(tosyloxy)piperidine-1-carboxylate9560.0 mg
    65N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.660.0 mg
    66tert-butyl 4-(3-(4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidin-1-yl)propyl)piperidine-1-carboxylate86.560.0 mg
    67tert-butyl 4-(3-(tosyloxy)propyl)piperidine-1-carboxylate9360.0 mg
    68perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-ethoxybenzoate9360.0 mg
    69(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethan-1-amine98100.0 mg
    70(R)-1-(2-fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine98100.0 mg
    71(R)-1-(3-nitro-5-(trifluoromethyl)phenyl)ethan-1-amine94100.0 mg
    722-amino-5-bromo-4-methoxybenzamide97100.0 mg
    73(R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethan-1-amine95100.0 mg
    742-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione98310 mg
    75perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoate92120 mg
    763-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid97115 mg
    77N-(2-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide9650 mg
    78tert-butyl ((1r,4r)-4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)cyclohexyl)carbamate80110 mg
    795-(4-(2,2-dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione93100 mg
    802-(2,6-dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione100170 mg
    81perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-morpholinobenzoate96110 mg
    82N-(2-((1r,4r)-4-((3-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3-azaspiro[5.5]undecan-9-yl)(ethyl)amino)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide98.320 mg
    835-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-chloro-1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide10075 mg
    84N-(2-(1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide100180 mg
    85tert-butyl 4-((1S,4s)-4-(4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)cyclohexane-1-carbonyl)piperazine-1-carboxylate91100 mg
    86N-(2-((1r,4r)-4-formylcyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide97.64105 mg
    87perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoate90.86115 mg
    88N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.47152 mg
    895-hydroxy-3-(2-(hydroxymethyl)-1H-indol-3-yl)isoindolin-1-one97.13116 mg
    90tert-butyl 4-(6-(difluoromethoxy)-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidine-1-carboxylate97.46106 mg
    91tert-butyl 9-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)-3-azaspiro[5.5]undecane-3-carboxylate97.85110 mg
    92tert-butyl 9-(4-(6-methoxy-5-nitro-2H-indazol-2-yl)cyclohexyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate96.8960 mg
    93N-(2-(1-(2-(3-azaspiro[5.5]undecan-9-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide98.12139 mg
    94N-(2-((1r,4r)-4-formylcyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.1581 mg
    95benzyl 2-(2-(tosyloxy)ethyl)-7-azaspiro[3.5]nonane-7-carboxylate91.63146 mg
    963-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indole-2-carbaldehyde9058 mg
    97tert-butyl 4-((3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indol-2-yl)methyl)piperazine-1-carboxylate80.83107 mg
    98N-(6-methoxy-2-((1r,4r)-4-((methylamino)methyl)cyclohexyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide95.91103 mg
    99tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate95237 mg
    1002A-196.051.3 g+300 mg
    101Pomalidomide-C6-CO2H99.3860 mg
    102Pomalidomide-C2-NH2 hydrochloride98.81244 mg
    103Pomalidomide-C3-NH2 hydrochloride99.6220 mg
    104Pomalidomide-C6-NH2 hydrochloride99.27185 mg
    105Pomalidomide-C7-NH2 hydrochloride99.36130 mg
    106Pomalidomide-C2-CO2H95.83380 mg
    107B-295.9460 mg
    108Pomalidomide-C5-CO2H95.19500 mg
    1092A-499.311.26 g
    110Pomalidomide-C9-CO2H98.8650 mg
    111B-997.19100 mg
    112B-896.06400 mg
    113B-1096.12160 mg
    1142A-296.61150 mg
    115Pomalidomide-PEG2-NH2 hydrochloride97.95400 mg
    116Pomalidomide-PEG1-NH2 hydrochloride96.34468 mg
    1172A-598.22168 mg
    118Pomalidomide-C8-NH2 hydrochloride99.18150 mg
    1195-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione97.1185 mg
    1204-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione98.6441 mg
    1215-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione99.950 mg
    1224-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione95.452 mg
    1235-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione991.547 g
    1242-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione903.5 g
    1252-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione90155 mg
    1261-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde90167 mg
    1275-(4-(hydroxymethyl)piperidin-1-yl)-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione99164 mg
    1282-(2,6-dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)azetidin-1-yl)isoindoline-1,3-dione98200 mg
    1292-(2,6-dioxopiperidin-3-yl)-4-(4-((4-hydroxypiperidin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione99134 mg
    1302-(2,6-dioxopiperidin-3-yl)-5-(3-hydroxyazetidin-1-yl)isoindoline-1,3-dione100101 mg
    1312-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoacetaldehyde8659 mg
    1325-(4-((4-(((R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pyrrolidin-1-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione10083 mg
    1332-(2,6-dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione96100 mg
    1342-(2,6-dioxopiperidin-3-yl)-5-(9-oxo-3-azaspiro[5.5]undecan-3-yl)isoindoline-1,3-dione96187 mg
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