Emai：marketing@medicilon.com.cn
业务咨询专线：400-780-8018
Tel: +1(626)986-9880(U.S. - West Coast)
0044 7790 816 954 (Europe)
Email: marketing@medicilon.com
地址：上海市浦东新区川大路585号
邮编：201299
电话：+86 (21) 5859-1500（总机）
传真：+86 (21) 5859-6369
© 2023 上海美迪西生物医药股份有限公司 保留所有权利 沪ICP备10216606号-3
业务咨询
中国：
Email: marketing@medicilon.com.cn
业务咨询专线：400-780-8018
（仅限服务咨询，其他事宜请拨打川沙总部电话）
川沙总部电话: +86 (21) 5859-1500
海外：
+1(626)986-9880(U.S. - West Coast)
0044 7790 816 954 (Europe)
Email:marketing@medicilon.com
Age-related neurodegenerative disorders are characterized by the progressive accumulation of misfolded and aggregated proteins. SNARE protein ykt6 plays a crucial role in proteostasis and lysosomal function by enhancing hydrolase trafficking under stressful conditions. Activating ykt6 by small-molecule farnesyltransferase inhibitors (FTIs) restores lysosomal activity and reduces a-synuclein in patient-derived neurons and mice. Pharmacokinetic studies revealed that after a single oral dose, the FTI (LNK-754) was cleared from plasma within 20 hours and could rapidly cross the blood-brain-barrier. Pharmacokinetic analysis was performed as a service provided by Medicilon.
Reference
相关新闻川沙总部
地址: 上海市浦东新区川大路585号
邮编: 201299
电话: +86 (21) 5859-1500（总机）
传真: +86 (21) 5859-6369
海外：
Email: marketing@medicilon.com
Tel: +1(626)986-9880(U.S. - West Coast)
Tel: 0044 7790 816 954 (Europe)
Tel: +82 70-8269-5849 (Korea)
Tel: +81 80-4421-6898 (Japan)
关于我们
