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KRAS蛋白包含4个结构域。KRAS蛋白由6条β-折叠链和5条-螺旋结构组成,形成两个主要结构域:G结构域和C端结构域。
KRAS protein contains 4 domains.KRAS protein is made up of 6 beta-strands and 5 alpha-helicies, which form two major domains: G-domain and C-terminal.
KRAS的G结构域由残基1-166组成,包括GTP结合口袋,该区域对于下游效应物和GTPase激活蛋白之间的相互之间作用至关重要。
The G-domain of KRAS, comprised of residues 1-166, includes the GTP-binding pocket, a region within which is essential for the interactions between the putative downstream effectors and GTPase-activating proteins.
G结构域是高度保守的,包括负责GTP-GTP交换的switch Ⅰ和switch Ⅱ区域。
The G domain is highly conserved and contains switch Ⅰ and switch Ⅱ loops, which are responsible for GDP-GTP exchange.
C端是一个包含CAAX基序的高变区,引导翻译后修饰并决定细胞膜锚定,该区域在RAS蛋白的生物活性调控中起着重要作用。/p>
The C-terminal, a hypervariable region including the CAAX motif, guides posttranslational modifications and determines plasma membrane anchoring. This region plays an important role in the regulation of the biological activity of RAS protein.