PDE1是与中枢和外周疾病密切相关的药物靶点，研究人员合成一种PDE1 抑制剂在大鼠肝微粒体中具有良好的代谢稳定性。其中稳定性测试通过美迪西进行

Phosphodiesterase-1 (PDE1) is a promising drug target closely related to central and peripheral diseases. Compound 2j with the IC₅₀ of 21 nM against PDE1B, shows good metabolic stability in the rat liver microsomes. Stability test in the rat liver microsomes were performed by Medicilon.

Reference:

Bei Zhang, et al. Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors. Bioorg Chem. 2021 Sep;114:105104. doi: 10.1016/j.bioorg.2021.105104.