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A PROTAC-based androgen receptor (AR) degrader is a bifunctional small molecule, consisting of an AR ligand that binds to AR protein, and a ligand that binds to and recruits an E3 ligase complex, tethered together through a linker. Researchers report the discovery of exceptionally potent and orally bioavailable PROTAC AR degrader ARD-2585 (Compound 43). ARD-2585 is a promising AR degrader for extensive investigations for the treatment of advanced prostate cancer.
The liver microsomal stability assay was performed by Medicilon.
The plasma stability assay was performed by Medicilon.
The hERG assay was performed by Medicilon.
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地址: 上海市浦东新区川大路585号
邮编: 201299
电话: +86 (21) 5859-1500（总机）
传真: +86 (21) 5859-6369
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Email: marketing@medicilon.com
Tel: +1(626)986-9880(U.S. - West Coast)
Tel: 0044 7790 816 954 (Europe)
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