疼痛动物模型介绍

古往今来，人类使用了许多不同的止痛方法。然而仍然有一些疼痛症状无法得到有效缓解，由于不同程度的镇痛药物不良反应，或药效强度和持续时间都不理想，对疼痛的预防和治疗仍达不到理想的程度。

Throughout the ages, man has used many different remedies for pain relief.However, there are still some pain symptoms that can't be effectively alleviated, because of different degrees of analgesic drug adverse reactions or efficacy intensity and duration is not ideal. Thus, the prevention and treatment of pain is still not up to the ideal degree.

具有不同作用机制和不同镇痛类型的各种止痛药需要在临床试验前通过相应的动物模型进行评估。当动物在实验方案中经理疼痛时，会触发一系列生理、激素、生化和行为变化，这与人类的反应方式如出一撤。

Various analgesics with different mechanisms of action and different types of analgesia need to be evaluated by corresponding animal models before clinical trials.When animals experience pain during an experimental protocol, a cascade of physiological, hormonal ,biochemical, and behavioral alterations is triggered that's simile the same way of human reaction.

我们可以选择相应的镇痛动物模型来评价新的镇痛药物。疼痛的动物模型旨在模拟不同的临床疾病，以更好地评估潜在的机制和潜在的治疗方法。

Therefore, we can choose the corresponding pain animal model to evaluate the new analgesic drugs.Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments.

目前，美迪西具有不同类型的疼痛包括急性疼痛、炎症性疼痛和神经性疼痛。我们已经开发了许多常见的方法，用于诱导与临床疼痛综合征相关的每种疼痛表型，以及评估每种模型肿疼痛的主要行为测试。

Currently, Medicilon possesses different types of pain, including acute pain, inflammatory pain, and neuropathic pain.We have developed many common methods used for inducing each of the pain phenotypes related to clinical pain syndromes,as well as the main behavioral tests for assessing pain in each model.

我们也开发了各种临床相关的疼痛模型，这些模型已经过验证，以有效地测试新的治疗候选药物。

We have developed a variety of clinically relevant pain models that have been validated to effectively test new therapeutic candidates.