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搜索结果包含 inflammatory 的内容

Jul 06,2023
ANO1是一个潜在的镇痛靶点。DFBTA是一种有效的ANO1抑制剂,具有优异的药代动力学特性。体内PK测试通过美迪西进行
Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs. Developing new analgesic drugs remains important to address the unmet medical needs of chronic pain pat
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ANO1是一个潜在的镇痛靶点。DFBTA是一种有效的ANO1抑制剂,具有优异的药代动力学特性。体内PK测试通过美迪西进行
Jul 05,2023
RIPK2激酶参与多种慢性炎症,UH15-15抑制RIPK2激酶并具有良好的体外ADME和PK特性,PK研究通过美迪西进行
Receptor interacting protein kinase-2 (#RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain cell signaling, a pathway implicated in numerous
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RIPK2激酶参与多种慢性炎症,UH15-15抑制RIPK2激酶并具有良好的体外ADME和PK特性,PK研究通过美迪西进行
Jul 05,2023
苯并咪唑衍生物XY123是一种口服有效的选择性RORγ反向激动剂。在本研究中,所有肝微粒体测定均通过美迪西进行
Receptor-related orphan receptor γ (RORγ) has emerged as an attractive therapeutic target for the treatment of cancer and inflammatory diseases. XY123 potently inhibits the RORγ transcription activity
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苯并咪唑衍生物XY123是一种口服有效的选择性RORγ反向激动剂。在本研究中,所有肝微粒体测定均通过美迪西进行
Jul 05,2023
设计、合成和评估具有体内抗炎活性的RIPK1抑制剂,PK研究通过美迪西进行
RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, researchers r
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设计、合成和评估具有体内抗炎活性的RIPK1抑制剂,PK研究通过美迪西进行
Jun 28,2023
发现用于局部治疗牛皮癣的新型PDE4抑制剂,小鼠、大鼠和人肝微粒体的代谢稳定性实验通过美迪西测定
Psoriasis is a common immune-mediated skin disorder manifesting in abnormal skin plaques, and PDE4 is an effective target for the treatment of inflammatory diseases such as psoriasis.
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发现用于局部治疗牛皮癣的新型PDE4抑制剂,小鼠、大鼠和人肝微粒体的代谢稳定性实验通过美迪西测定